10-6


Suppression of nuclear factor-Kappa B activation pathway by spice-derived phytochemicals

B. B. AGGARWAL, Dept. of Experimental Therapeutics, Univ. of Texas M.D. Anderson Cancer Center, Cytokine Research Lab., Houston, TX 77030

The activation of nuclear transcription factor-kappa B (NF-κB) has now been linked with a variety of inflammatory diseases including cancer, atherosclerosis, myocardial infarction, diabetes, allergy, asthma, arthritis, Crohn's disease, multiple sclerosis, Alzheimer's disease, osteoporosis, psoriasis, septic shock, and AIDS. Extensive research in the last few years has shown that the pathway that activates this transcription factor can be interrupted by phytochemicals derived from spices such as turmeric (curcumin), red pepper (capsaicin), cloves (eugenol), ginger (gingerol), cumin, anise and fennel (anethol), basil and rosemary (ursolic acid), garlic (diallyl sulfide, S-allylmercaptocysteine, ajoene), and pomegranate (ellagic acid). For the first time, therefore, research provides “reasoning for seasoning.”

Session 10, Natural antioxidants in herbs and spices
2:30 PM - 5:30 PM, Sunday PM Room 392

2005 IFT Annual Meeting, July 15-20 - New Orleans, Louisiana