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D. FILBIEN and J. Tauzin. INGREDIA SA, INGREDIA SA, 51-53 Avenue F. Lobbedez, ARRAS, 62000, France Stress-related disorders affect nearly 450 million people. The cost of work-related stress per year is estimated to be $200 billion worldwide. Lactium™ is a milk protein hydrolysate with regulating properties on stress effects, that could be an interesting alternative to increasing psychotropic drugs misuses by people. Lactium™ stems from years of research, including close collaborations with institutional or private research laboratories. The stress modulating effects of this hydrolysate has been initially investigated in vivo on rats and in vitro on biological receptors (Laboratoire des Biosciences de l'Aliment, Nancy, France). The bioactive peptide has been then purified, identified as alphaS1-CN (f91-100) and modeled. An industrial scale process was designed to produce Lactium™, a food grade milk protein hydrolysate containing the bioactive peptide. The efficacy of Lactium™ was demonstrated on rats, and neither toxicity nor side effects were evidenced in pre-clinical studies using appropriate models. Double blind clinical studies versus placebo were then engaged in Clinical Research Centers, checking the efficacy and the safety profile of Lactium™ on healthy human volunteers (190 volunteers on the whole). The results, using validated biological parameters, showed the regulating effect of Lactium™, like a smaller increase of the mean blood pressure response to stress. This efficacy was observed without any side effects in humans, for example no alteration of ambulatory haemodynamic parameters or arousal. Finally, these effects were confirmed in a consumer study where Lactium™ showed a significant reduction of different stress-linked troubles. Lactium™, a patented food grade ingredient with clinically proven efficacy and without any side effects, is designed to be easily incorporated into food matrices as chocolates or beverages, and also in dietary supplements.
Session 106, Protein hydrolysates and/or bioactive peptides in nutraceuticals and functional foods
2005 IFT Annual Meeting, July 15-20 - New Orleans, Louisiana |