11-5 |
|
J. A. MILNER, National Cancer Institute, U.S. National Institutes of Health, Nutritional Science Research Group, 6130 Executive Blvd., Ste. 3160, Rockville, MD 29892 Mounting evidence points to the ability of various dietary components to modify growth, development, performance and disease prevention. Likewise, it is also evident that wide variability in the response occurs among individuals. This variation, which may be inhibitory or stimulatory depending on the specific component, may arise from differences in the absorption, metabolism, and target(s) for a food component, or to its interaction with genetic or environmental factors. Several NIH grant mechanisms (R01, R21, P01, U54 etc.) are designed to foster preclinical and clinical research to help identify individuals who will benefit maximally or be placed at jeopardy by dietary interventions. The judicious use of nutrigenomics, (the study of any genetic or epigenetic interaction with a food component), and nutritional transcriptomics, proteomics and metabolomics approaches will likely be key to defining the biological responsiveness among individuals. This presentation will focus on grant opportunities and strategies that may assist in incorporating these newest “omics” approaches and technologies into research programs aimed at defining the role of bioactive food components as health determinants. The uses and limitations of various models, including transgenic and knockouts, to “discover” how food components modify carcinogen activation/detoxification, alter rates of cellular proliferation, influence apoptosis and modify angiogenesis, etc. will be briefly reviewed. Likewise, information will be shared about research funding opportunities for the translation of this discovery information into the “development” and “delivery” phases, including those for small business. Resources for obtaining information about specific Request for Applications (RFAs) and Program Announcements (PAs) available at the NIH will be reviewed. Attention will also be given to opportunities that are available for new investigators through training or exploratory award mechanisms. Undeniably, research and training are at the core of future biological advances, including those related to foods and health. While the available opportunities are not without challenges, the personal and public satisfaction that will arise from success is overwhelming.
Session 11, Prismatic views of grantsmanship and federal funding opportunities
2005 IFT Annual Meeting, July 15-20 - New Orleans, Louisiana |