Session F6: Room N-119 | |||
Friday AMFORUM: Oxidative stress, hypoxia, angiogenesis, and chronic diseases: The potential contribution of functional foods | |||
| Moderator(s): | J. N. Losso, Louisiana State Univ. Agricultural Center F. Shahidi, Memorial Univ. of Newfoundland | ||
| Panelist(s): | F. Shahidi, Memorial Univ. of Newfoundland J. N. Losso, Louisiana State Univ. Agricultural Center Z. Dong, Hormel Institute R. Natarajan, Beckman Research Institute H. Bawadi, Louisiana State Univ. D. Bagchi, Creighton Univ. Medical Center | ||
| Time: | 9:00 AM | ||
| The “angiogenic switch”, which is the conversion of quiescent endothelial cells to a proliferative state, has been recognized for its role in the progression and complications of several angiogenic diseases such as arthritis, cancer, diabetes retinopathy and nephropathy, atherosclerosis, HIV, AIDS, bowl disease, and obesity. These diseases commonly contain pockets of cells growing in absence of oxygen (hypoxic). Hypoxic cells are known to be resistant to chemo- and conventional therapies. Increased levels of reactive oxygen species (ROS), produced either by normal physiological processes or by exogenous factors, have been identified as a major initiator of a pathological process that translates into cellular aging, degenerative diseases, cell death, shortened life expectancy, and death. The role of the mitochondrion, the major source of oxygen consumption for ATP production and reactive oxygen species generation, will be discussed in light of its involvement in the onset and progression of degenerative diseases. The biochemical characterization of potential steps involved in the onset and or progression of degenerative diseases and the connection between oxidative phosphorylation (OXPHOS) and the potential molecular events that occur before and after the "angiogenic switch" will be presented. Diabetes complications, an angiogenic disease characterized by both insufficient and excessive blood vessels, will be covered from basic to clinical aspects. Obesity will also be discussed as an "angiogenic disease". The potentials of anti-angiogenic functional foods for obesity and diabetes complications prevention will be presented. Food-derived bioactive compounds with potentials to and the mechanisms by which functional foods may prevent angiogenic diseases will be discussed. Future trends in anti-angiogenic functional foods and the way food may be designed in the future will also be addressed. An open discussion on the way we may have to train future food scientists and nutritionists and carry functional food research will follow. | |||