114E-25 |
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H.-S. CHUN1, E.-H. Choi1, H. J. Kim1, and Y. S. Yoon2. (1) Korea Food Research Institute, San 46-1, Baekhyun-dong, Bundang-gu, Sungnam, 463-746, South Korea, (2) Laboratory of Cancer Research, Korea Institute of Oriental Medicine, 132-100, Seoul, South Korea 5-Fluorouracil (5FU) is one of the most important active chemotherapeutic agents for the treatment of solid tumors such as carcinomas of the breast and colon, and soft tissue sarcomas. However, the potentially lethal, dose-dependent side effects on myocardial or hematogenous tissues have greatly limited the use of this effective antitumor drug. Given that a number of people suffer from cancer every year, it is important to reduce 5FU-induced toxicity or adverse effects. The objective of this study was to investigate the effect of anthocyanin rich extract from Vaccinium myrtillus L. (AREB) on the chemosensitivity and toxicity of 5-fluorouracil in vitro and in vivo model. The addition of AREB to MCF-7 human breast cancer cells enhanced the efficacy of growth inhibition by 5FU, resulting in growth inhibition similar to the level observed with high doses of 5FU. On the other hand, the addition of AREB was found to have the protective potential against 5FU-induced toxicity in normal human cardiomyocytes. Furthermore, C57BL/6 mouse orally treated with 500mg/kg of AREB for 10 days showed a statistically significant increase in numbers of red blood cell, hemoglobin, platelet, neutrophile and monocyte against the 5FU-induced damages. These results suggest that AREB may have protective potential against the 5-FU-induced toxicity and/or the ability to enhance the effectiveness of 5FU treatments.
Session 114E, Nutraceuticals & Functional Foods: Bioactivity measurement and mechanism
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