33G-28 |
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Y.-C. CHAN1, C.-K. Hsu2, Y.-C. Chung1, J.-W. Liao3, and C.-P. Hsieh4. (1) Food and Nutrition, Providence University, 200 Chung ¡V Chi Rd, Taichung, 433, Taiwan, (2) Applied life science, Taichun healthcare and management university, 500 Lui-Fang Rd., Wu-Fang, Taichung, 413, Taiwan, (3) Division of Applied Toxicology, Taiwan Agricultural Chemical and Toxic Substances Research Institute, Taichung, Taiwan, (4) Department of Food and Nutrition, Providence University, Taichung, 433, Taiwan Evidence indicates that certain non-digestible oligosaccharides can be utilized by probiotics and reduce the risk of colon cancer. However, the inhibitory effects of xylooligosaccharides (XOS) on colon cancer are not well documented. The purpose of this study was to evaluate the effects of xylooligosaccharides on the alterations of cecal microbiota, pH, weight, serum lipids, and also to determine the effects on the inhibition of colon precancerous lesion in rats. Male Sprague-Dawley rats were randomly assigned to four dietary groups, including the control, 1,2-dimethylhydrazine (DMH), DMH plus XOS, and DMH plus fructooligosaccharides (FOS) groups. All the rats except the control group were given 15 mg DMH per kg body weight once weekly for 2 weeks, and then the experiment diet containing 6% of XOS or FOS was fed to the rats for the consecutive 35 days. Both the XOS and FOS supplementations significantly lowered the cecal pH and serum triglyceride levels, and increased the cecal total weight and bifidobacteria population. Moreover, both the XOS and FOS showed significant inhibition on the colon precancerous lesion induced by DMH, indicating by the lower numbers of total aberrant crypt foci (ACF) in the colon of the rats fed with the XOS or FOS containing diet. The supplementation of the XOS was more effective on improving bifidobacteria population than the FOS. In conclusion, our results suggested that the supplementation of the XOS or FOS was successful on inhibiting the precancerous lesions, promoting the growth of bifidobacteria and lowering the cecal pH value. Therefore, XOS and FOS containing diets were considered to be beneficial in improving gastrointestinal health. Furthermore, the XOS seemed to be more efficient than the FOS dietary supplementation.
Session 33G, Nutraceuticals & Functional Foods: Lipid and probiotic functional foods
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