46F-10 |
Effects of Aralia elata Seemann ethanol extract on antioxidant and lipid metabolism in rats administered with benzo(メ)pyrene |
M. E. Jung1, S. M. Nam2, H. S. Ryu3, C. K. Chung1, I. J. Kang4, and Y. S. LEE4. (1) Dept of Food and Nutrition, Hallym Univ., Okchon-dong, Chunchon, 200-702, South Korea, (2) Dept of Hotel Culinary Arts, Chong In Collage, Jungup, 580-712, South Korea, (3) Faculty of Food Sci. and Biotechnology, Bukyong Nat'l Univ., Daeyeon-dong, Busan, 608-737, South Korea, (4) Food & Nutrition, Hallym Univ., 1 Okchon-Dong, School of Life Sciences, Chunchon, 200-702, South Korea Aralia elata Seemann is an edible mountain vegetable in Korea and contains various functional components such as saponins and alkaloids. For a long time in Korean traditional medicine, barks and roots have been used in treating hypoglycemia, ulcer, cancer, diabetes and gastritis. This study has examined the effects of Aralia elata Seemann ethanol extract on antioxidant enzyme systems and lipid metabolism in rats along with benzo(メ)pyrene(B(メ)P) administration. Male Sprague Dawley(SD) rats weighing approximately 100g were divided into four groups : The control(C), Aralia ethanol extract fed group(CE), B(メ)P treated group(CB) and B(メ)P and Aralia ethanol extract administered group(CBE). The ethanol extracts of Aralia elata Seemann(50Х/Kg body wt.) were fed to rats for 4 weeks by stomach tubing. Liver antioxidant enzyme activities and serum lipids were measured. The extracts administration increased antioxidant activities of glutathione sulfur transferase(GST) by 50.9%(p<0.05) comparing to the control. Total superoxide dismutase(SOD) and Cu,Zn-SOD activities were also increased by 6.8% and 18.4%, respectively. Catalase activities were increased by 50% with the extracts feeding. Combined administration of B(メ)P and the extracts increased GST activity. Although total SOD activity was decreased, Cu,Zn-SOD was greatly enhanced from 0.10 unit to 0.18 unit. Serum メ-tocopherol was markedly increased by the extract(p<0.05). Administration of B(メ)P reduced メ-tocopherol levels in the serum. Feeding of the ethanol extracts decreased serum cholesterol. On the other hand, serum HDL was increased by 35% (p<0.05). Serum cholesterol and triglyceride in CBE group was decreased comparing to the group CB but serum HDL was increased by 46% (p<0.05). The about results indicate that Aralia elata Seemann ethanol extracts stimulate antioxidant functions as well as a strong hypolipidemic effects in vivo. Further research may be necessary for the identification of the biologically active materials involved in this study.
Session 46F, Nutrition
|