15E-4 |
Study on dietary supplementation of Monascus-fermented products on retardation of aging in senescence-accelerated mice |
H. P. OU, S. C. Yang, and M. F. Wang. Food & Nutrition, Providence Univ., 200 Chung-chi Rd., Shalu, Taichung, 433, Taiwan Monascus species has been confirmed to produce many metabolites, which were advantageous for human beings. Some investigators have reported on adjustment of plasma lipid, blood tension and antioxidant action in rats. However, the investigation was limited on aging. The senescence-accelerated mice (SAM-P/8) are known to be an animal model for accelerated aging. The SAM-P/8 strain shows age-related deterioration of learning and memory at an earlier age. The objective of this study was to evaluate the possibility of Monascus-fermented products (MPs) on retardation of aging in mice. The mice were fed contain 0.03% MPs based of AIN-76 diet since 3- to 11-month-old. The changes of body weight, intake and feed efficiency of mice, which fed different diet, are not significantly different. Supplementation of MPs are increased the passivity behavior, hair glossiness, coarseness and reduced lordkyphosis of the spine in mice. In learning and memory abilities of 10-month-old mice, the active shuttle avoidance test was used. The control group were significantly lower in learning and memory than MPs group (p°Õ0.05). There was no significantly difference in the tissue organs weight, except spleen. In liver total antioxidant ability, the MPs group was significantly higher than control group in male 11-month-old mice. These results suggested that dietary supplementation of Monascus-fermented products may be considered for retardation of aging.
Session 15E, Nutraceuticals & Functional Foods I
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